protein kinase CK2

[Michael Ashburner (Genetics)]

I agree that the defn of the complex could be better written, but
otherwise I disagree with you.

Michael

> From owner-go at genome.stanford.edu Tue Sep 03 23:40:52 2002
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> From: Pankaj Jaiswal <pj37 at cornell.edu>
> Organization: Cornell University
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> To: "go at geneontology.org" <go at genome.Stanford.EDU>,
>         brie <gramene at brie.cshl.org>
> Subject: protein kinase CK2
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> 
> Hi Midori,
> 
> I figured out 4 existing terms for casein kinase II
> 1	casein kinase II
> 2	casein kinase II complex
> 3	casein kinase II catalyst
> 4	casein kinase II regulator ( comment: do we mean regulator of CK2 or CK2
> acting as a regulator)
> 
> all four had the same DBXref
> 
> the molecule CK2 is a heterotetrameric in structure with 2 catalytic alpha sub
> units and two regulatory beta sub units. I suppose that is what the DAG means by
> having 3 AND 4 as a PARTOF 1. 
> 
> I think they should be rephrased to 
> 
> %casein kinase II ; synonym:protein kinase CK2 ; Synonym:protein kinase CKII
>  <casein kinase II alpha sub unit  or say   protein kinase CK2 catalytic sub
> unit
>  <casein kinase II beta sub unit ; or say   protein kinase CK2 regulatory sub
> unit
> 
> Also having it as a complex creates a confusion. I think it should remain as an
> enzyme and not as part of component ontology. This is a real tricky thing to put
> the same thing with two different attributes just to have it as instances of two
> ontologies. I still believe all the enzymes that have assembled in a complex for
> their activity should be instances of function only and NOT as component. It
> generally creates a lot of confusion. Its the same case with ATPases and lots of
> other enzymes
> 
> casein kinase II and casein kinase II complex is the same thing. Merely defining
> it in a different way does not mean that they are two different terms such as 
> 
> casein kinase II : Catalysis of the reaction: casein + ATP = phosphocasein +
> ADP.
> casein kinase II complex : An enzyme that catalyzes the phosphorylation of
> casein.
> 
> You may consider revising the definitions of casein kinase II and casein kinase
> II complex by suggesting its action on a generic substrate.
> 
> Please refer the article : PMID: 7896000
> Protein kinase CK2 is a ubiquitous eukaryotic ser/thr protein kinase present in
> the nucleus and cytoplasm. CK2 is known to phosphorylate more than 100
> substrates, many of which are involved in the control of cell division and in
> signal transduction.
> 
> Another reference is from IUBMB:
> http://www.chem.qmw.ac.uk/iubmb/enzyme/EC2/7/1/37.html
> 
> Cheers
> 
> Pankaj
>