protein kinase CK2

[Pankaj Jaiswal]

Hi Midori,

I figured out 4 existing terms for casein kinase II
1	casein kinase II
2	casein kinase II complex
3	casein kinase II catalyst
4	casein kinase II regulator ( comment: do we mean regulator of CK2 or CK2
acting as a regulator)

all four had the same DBXref

the molecule CK2 is a heterotetrameric in structure with 2 catalytic alpha sub
units and two regulatory beta sub units. I suppose that is what the DAG means by
having 3 AND 4 as a PARTOF 1. 

I think they should be rephrased to 

%casein kinase II ; synonym:protein kinase CK2 ; Synonym:protein kinase CKII
 <casein kinase II alpha sub unit  or say   protein kinase CK2 catalytic sub
unit
 <casein kinase II beta sub unit ; or say   protein kinase CK2 regulatory sub
unit

Also having it as a complex creates a confusion. I think it should remain as an
enzyme and not as part of component ontology. This is a real tricky thing to put
the same thing with two different attributes just to have it as instances of two
ontologies. I still believe all the enzymes that have assembled in a complex for
their activity should be instances of function only and NOT as component. It
generally creates a lot of confusion. Its the same case with ATPases and lots of
other enzymes

casein kinase II and casein kinase II complex is the same thing. Merely defining
it in a different way does not mean that they are two different terms such as 

casein kinase II : Catalysis of the reaction: casein + ATP = phosphocasein +
ADP.
casein kinase II complex : An enzyme that catalyzes the phosphorylation of
casein.

You may consider revising the definitions of casein kinase II and casein kinase
II complex by suggesting its action on a generic substrate.

Please refer the article : PMID: 7896000
Protein kinase CK2 is a ubiquitous eukaryotic ser/thr protein kinase present in
the nucleus and cytoplasm. CK2 is known to phosphorylate more than 100
substrates, many of which are involved in the control of cell division and in
signal transduction.

Another reference is from IUBMB:
http://www.chem.qmw.ac.uk/iubmb/enzyme/EC2/7/1/37.html

Cheers

Pankaj